What is the significance of Psammoma bodies?
Psammoma bodies in cervicovaginal smears. Psammoma bodies have been considered a worrisome finding that are indicative of occult cervical, endometrial, tubal, or ovarian malignancy in up to 60% of historic case reports.
Where are Psammoma bodies found?
Psammoma bodies (PBs) are concentric lamellated calcified structures, observed most commonly in papillary thyroid carcinoma (PTC), meningioma, and papillary serous cystadenocarcinoma of ovary but have rarely been reported in other neoplasms and nonneoplastic lesions.
What are Psammoma bodies thyroid?
The presence of psammoma bodies is a diagnostic characteristic of papillary thyroid carcinoma. It is defined as spherical calcified foci with concentric laminations,1, 19, 20 and is usually located within stromal stalks of tumor papillae, and is distinct from intrafollicular inspissated colloid.
Are Psammoma bodies malignant?
They also have a concentric laminated, or onion-like, appearance. Psammoma bodies are generally found in damaged tissues, and are commonly associated with malignant cancers as well as some benign, non-cancerous conditions.
What cancers have Psammoma bodies?
Psammoma bodies are found in a diverse group of tumors which include:
- papillary thyroid carcinoma.
- papillary serous carcinoma of the endometrium.
- melanotic schwannoma (psammomatous variety)
- meningioma.
- mesothelioma.
- serous cystadenocarcinoma of the ovary.
- adenocarcinoma of lung.
What is serous Cystadenocarcinoma?
Ovarian serous cystadenocarcinoma is the malignant form of ovarian serous tumor, the most common type of ovarian epithelial tumor. It is the most common type of ovarian malignancy.
Does Prolactinoma have Psammoma bodies?
Prolactinomas. These tumors are chromophobic and contain spheroid nuclei with prominent nucleolus. Psammoma bodies and interstitial amyloid deposits, which are seen occasionally, are typical for this adenoma type.
What causes a serous cystadenoma?
What is a serous cystadenoma? A serous cystadenoma is a very common non-cancerous type of ovarian tumour. It develops from the cells on the surface of the ovary. While these tumours are non-cancerous, they can grow to be very large in size and as a result can cause significant symptoms for many patients.
What brain tumor has Psammoma bodies?
Additionally, psammoma bodies can be found in meningiomas, or tumors that form on the meninges (the membrane that covers the brain and spinal cord inside the skull). As many as 90% of meningiomas are benign and non-cancerous.