Is sitagliptin good for heart?
In conclusion, sitagliptin increases the risk of heart failure hospitalization within one year of its use, but reduces the risk thereafter. Some factors predisposing to sitagliptin-related heart failure are worthy of attention in clinical practice.
What is TECOS Trial?
TECOS: A Randomized, Placebo Controlled Clinical Trial to Evaluate Cardiovascular Outcomes After Treatment With Sitagliptin in Patients With Type 2 Diabetes Mellitus and Inadequate Glycemic Control. Actual Study Start Date : December 10, 2008. Actual Primary Completion Date : March 30, 2015.
How effective is sitagliptin?
Conclusion. In routine clinical practice, sitagliptin produces a significant reduction in mean HbA1c (0.8%) within the first 6 months of use which corresponds to efficacy data obtained in controlled clinical trials. However, this reduction was lesser, 7 to 12 month later.
What is the mode of action of sitagliptin?
Abstract. Sitagliptin is a member of the gliptin class of antidiabetic medications. Its mechanism of action is through inhibition of dipeptidyl peptidase-4 (DPP-4), an enzyme that acts to degrade and inactivate glucagon-like peptide-1 (GLP-1).
What are the side effects of sitagliptin?
The most common side effects of JANUVIA include upper respiratory infection, stuffy or runny nose and sore throat, and headache. JANUVIA may have other side effects, including stomach upset and diarrhea, swelling of the hands or legs, when JANUVIA is used with metformin and rosiglitazone (Avandia ®).
Can linagliptin cause heart failure?
Within the class of dipeptidyl peptidase-4 inhibitors used for the treatment of hyperglycemia in type 2 diabetes mellitus, with cautions and warnings about an increased risk for heart failure for some but not all members of the class, these data provide robust assurance that linagliptin does not increase heart failure …
How does Jardiance help with heart?
Key secondary endpoint analyses from the trial demonstrated that Jardiance reduced the relative risk of first and recurrent hospitalization for heart failure by 30%. Additionally, the rate of decline in eGFR, a measure of kidney function decline, was slower with Jardiance than with placebo.
What is the best time to take sitagliptin?
(You may be prescribed a lower strength of tablet if you have a problem with the way your kidneys work.) You can generally take the tablet at a time of day to suit you, but it is best to take your doses at the same time of day each day. You can take sitagliptin before or after a meal.
Which is better sitagliptin or metformin?
Conclusions: In this 24-week monotherapy study, sitagliptin was non-inferior to metformin in improving HbA(1c) in treatment-naïve patients with type 2 diabetes. Although both treatments were generally well tolerated, a lower incidence of gastrointestinal-related adverse experiences was observed with sitagliptin.
What are the benefits of sitagliptin?
Sitagliptin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.
How safe is linagliptin?
In patients treated with linagliptin in the present analysis, incidence of severe hypoglycemia was very low, body weight and renal function remained stable, and no cases of drug-related renal failure were reported, suggesting that linagliptin can be used safely in all patients and even in this highly susceptible …
Is sitagliptin safe for long-term cardiovascular outcomes?
In the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS), we assessed the long-term cardiovascular safety of adding sitagliptin to usual care, as compared with usual care alone, in patients with type 2 diabetes and established cardiovascular disease.
How many patients add sitagliptin to their existing therapies?
In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients.
How much sitagliptin should I take to improve my EGFR?
Patients were randomly assigned in a 1:1 ratio to receive either sitagliptin at a dose of 100 mg daily (or 50 mg daily if the baseline eGFR was ≥30 and <50 ml per minute per 1.73 m 2) or matching placebo. An interactive voice-response system assigned the study medication in a double-blind manner, blocked within each site.
What is the mechanism of action of sitagliptin?
Sitagliptin, an orally administered dipeptidyl peptidase 4 (DPP-4) inhibitor, prolongs the action of incretin hormones, including glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide, by inhibiting their breakdown.