What are Aurora kinase inhibitors?

What are Aurora kinase inhibitors?

Aurora kinase inhibitors were initially aimed to target solid tumors including ovarian, breast, lung and colon. Despite the wide use of different chemical classes of Aurora kinase inhibitors in clinical trials, a limited efficacy against solid tumors was observed.

What do Aurora kinases do?

Aurora kinases are serine/threonine kinases that are essential for cell proliferation. They are phosphotransferase enzymes that help the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation.

Is Alisertib FDA approved?

However, alisertib is not currently approved by the Food and Drug Administration (FDA) in the United States for lymphoma. With regard to pralatrexate, which is FDA approved for relapsed or refractory PTCL, the phase 1 and 2 trials cumulatively included 3 subjects with ATLL.

What is the difference between spindle fibers and mitotic spindle?

Spindle fibers form a protein structure that divides the genetic material in a cell. During mitosis, the spindle fibers are called the mitotic spindle. Meanwhile, during meiosis, the spindle fibers are referred to as the meiotic spindle.

What events are controlled by mitotic spindle?

These basic events of mitosis include chromosome condensation, formation of the mitotic spindle, and attachment of chromosomes to the spindle microtubules. Sister chromatids then separate from each other and move to opposite poles of the spindle, followed by the formation of daughter nuclei.

Does Polo kinase depend upon cyclins?

Cyclin-dependent kinases (Cdks), polo-like kinases (Plks) and Aurora kinases play central roles in this process. Polo kinase (Plk1 in humans) regulates a wide range of events in mitosis and cytokinesis. To ensure the accuracy of these processes, polo activity itself is subject to complex regulation.

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