What is a myxoid neoplasm?
Myxoid tumors of soft tissue constitute a heterogeneous group of neoplasms characterized by the presence of a myxoid stromal matrix, which appears on H&E as an amorphous material and may be confused with edema. Superficial myxoid lesions in general are benign and deep ones are malignant.
Is a myxoid neoplasm cancer?
Myxoid/round cell liposarcoma, or MRCLS, is one of several types of liposarcoma. Liposarcoma is a rare cancer that grows in the cells that store fat in the body. MRCLS usually grows in the arms and legs. These tumors grow slowly, and they can spread to other parts of the body.
What is myxoid spindle cell neoplasm?
Myxoid leiomyosarcomas contain abundant myxoid material between smooth muscle cells. Histologically, the lesion is composed of spindle-shaped cells with a fascicular, reticular, or myxofibrosarcoma-like architecture (1). Treatment involves surgical excision.
Is spindle cell neoplasm benign or malignant?
Some tumours are made up almost entirely of spindle cells. These tumours can be either benign (non-cancerous) or malignant (cancerous). The type of tumour depends on the location in the body and the way the cells look when examined under the microscope. Most cancers made up of spindle cells are called sarcomas.
What is the survival rate of myxoid liposarcoma?
Low-grade myxoid and well-differentiated subtypes have a 5-year survival rate of 90% [17, 18, 20]. However, high-grade subtypes such as pleomorphic, and dedifferentiated liposarcomas have 5-year survival rates of only 30% to 62% [11, 13] and 44% to 75% [5, 20], respectively.
Is spindle cell neoplasm cancerous?
What is spindle cell sarcoma? Spindle cell sarcoma is a rare malignant (cancerous) tumour which can develop in the bone or soft tissue. It can arise in any part of the body but is most common in the limbs (arms and legs).
Does malignant fibrous histiocytoma have a highly myxoid appearance?
It has been generally recognized that malignant fibrous histiocytoma (MFH) may assume a highly myxoid, hypocellular appearance. Eighty cases of malignant fibrous histiocytoma having varying degrees of myxoid change were reviewed. These tumors typically arose on the extremities (leg, 61%; arm, 21%) o …
What is the Cellular variant of myxoma?
Myxomas often display either focal or more complete areas of increased cellularity and vascularity. This pattern is often termed the “cellular variant” of myxoma. Although the increased cellularity may be alarming at first glance, mitoses, necrosis, pleomorphism, and hyperchromasia are notably absent.
What is the pathophysiology of myxoma?
Myxoma is a relatively hypocellular spindle cell neoplasm with extensive myxoid stroma. Myxomas tend to occur in large muscles and are benign. Interestingly, myxomas can be seen in the context of several heritable syndromes, including Carney complex and Mazabraud syndrome.
What is the difference between intramuscular and cellular myxoma?
Intramuscular myxoma is a hypocellular myxoid lesion with bland cytology, inconspicuous vessels, and nondestructive infiltration of adjacent tissues. Cellular myxoma is more cellular, more collagenous, and more vascular than conventional intramuscular myxoma. Lesions are negative for S-100 protein; EMA may be positive in core needle biopsies.