Is methylene blue poisonous?
Methylene blue is a safe drug when used in therapeutic doses (<2mg/kg). But it can cause toxicity in high doses.
When do you use methylene blue?
Methylene blue injection is used to treat a condition called methemoglobinemia. This condition occurs when the blood cannot deliver oxygen where it is needed in the body. This medicine is to be given only by or under the supervision of a doctor.
How does ifosfamide cause neurotoxicity?
The plausible mechanism for neurotoxicity due to ifosfamide is based on findings of increased level of glutaric acid and sarcosine in urine of the patients with encephalopathy precipitated by ifosfamide.
What is methylene blue used to treat?
What can methylene blue treat?
Methylene Blue oral is used to treat methemoglobinemia and urinary tract infections. Methylene Blue is also used as a dye or staining agent to make certain body fluids and tissues easier to view during surgery or on an x-ray or other diagnostic exam. Methylene Blue is available in generic form.
How quickly does methylene blue work?
Reports suggest that methylene blue up to six doses a day have resulted in improvement of symptoms within 10 minutes to several days.
Is methylene blue an effective prophylactic agent for ifosfamide-induced encephalopathy?
Methylene blue for the treatment and prophylaxis of ifosfamide-induced encephalopathy Ifosfamide (IFOS) is used in cancer treatment. Ifosfamide-induced encephalopathy (IIE) can result in treatment delay or discontinuation as well as morbidity and mortality. Cases using methylene blue (MB) in acute and prophylactic treatments are discussed.
What is ifosfamide-induced encephalopathy (IIe)?
Ifosfamide (IFOS) is used in cancer treatment. Ifosfamide-induced encephalopathy (IIE) can result in treatment delay or discontinuation as well as morbidity and mortality.
Is methylene blue effective in the treatment of idiopathic inflammatory demyelinating syndrome?
The use of methylene blue (MB) for the treatment and prophylaxis of IIE was first reported in 1994 [2]. Since then, there have been sporadic reports on its efficacy in such treatments. Several models have been postulated to explain its mechanism of action in counteracting IFOS’s neurotoxic effects.
Can thiamine and hydration prevent ifosfamide-induced encephalopathy?
She eventually received chimeric antigen receptor T-cell therapy. Our report demonstrates the use of hydration, methylene blue, and thiamine as a successful secondary prevention regimen for ifosfamide-induced encephalopathy. Keywords: Cancer; encephalopathy; ifosfamide; methylene blue; thiamine.