What are the parts of bioreactor?
A bioreactor is a device that consists of various features such as an agitator system, an oxygen delivery system, a foam control system, and a variety of other systems such as temperature & pH control system, sampling ports, cleaning, and sterilization system, and lines for charging & emptying the reactor.
What is the design of bioreactor?
Bioreactor design is a relatively complex engineering task, which is studied in the discipline of biochemical/bioprocess engineering. Under optimum conditions, the microorganisms or cells are able to perform their desired function with limited production of impurities.
What should be the criteria for designing a bioreactor?
The general requirements of the bioreactor are as follows: The design and construction of bioreactors must keep sterility from the start point to end of the process. Optimal mixing with low, uniform shear. Adequate mass transfer, oxygen. Clearly defined flow conditions.
What is bioreactor explain with its types?
A bioreactor is a large vessel, which is used to grow culture on a large scale under optimum conditions to produce large quantities of the desired product, e.g. enzymes, antibodies, vaccines, etc. Types of bioreactors: Stirred-tank bioreactor. Simple stirred-tank bioreactor. Sparged stirred-tank bioreactor.
What are bioreactor and its utility?
(b) Bioreactor are vessels in which raw materials are biologically converted into specific products using microbial, plant or human cells. It provides optimal conditions for achieving the desired product by providing optimum growth conditions, pH, substrate salts, vitamins, oxygen, etc. (c) Downstream processing.
What is bioreactor PDF?
A bioreactor is a vessel or a device designed to sustain and support life of cell and tissue cultures. Page 4. The major types are: (1) Continuous Stirred Tank Bioreactors. (2) Bubble Column Bioreactors.
What is bioreactor used for?
Bioreactors are used to provide a tissue-specific physiological in vitro environment during tissue maturation. Based on the bioreactor technology, various tissue systems can be incubated in vitro.
What is the principle of bioreactor?
In bioreactors, the principle is the same; CO2 is introduced to the culture from a compressed gas cylinder. In bioreactors, the medium pH is continuously measured using a pH sensor and CO2 is added as needed.
What should be the basic points of consideration while designing a fermenter?
The basic points of consideration while designing a fermenter:
- Productivity and yield.
- Fermenter operability and reliability.
- Product purification.
- Water management.
- Energy requirements.
- Waste treatment.
What are the 3 common types of bioreactor?
The major types are:
Why are bioreactors used?
How does the design of a bioreactor affect process performance?
The decisions made in the design of the bioreactor might have a significant impact on overall process performance. Knowledge of reaction kinetics is essential for an understanding of the working of a biological reactor.
What is a bioreactor in biology?
3. Bioreactor A bioreactor may refer to a device or system meant to grow animal cells or tissues in the context of cell culture. These devices are being developed for use in tissue engineering or biochemical engineering.
What is the size of a bioreactor?
Bioreactor designs range from as small as a lab shake flask culture [22–27] to as large as an open pond the size of several football fields [28–30]. Kenneth P. Clapp, Eva K. Lindskog, in Biopharmaceutical Processing, 2018
What are some bioreactor design features found inside vessels?
Another important bioreactor design feature found inside vessels are spargers for subsurface gas delivery. Spargers are available in a variety of shapes and sizes; examples include ring spargers with drilled holes, sintered spargers, and single-orifice spargers, including open pipe ( Fig. 24.3 ).