What is FGFR1 gene?
The FGFR1 gene is involved in a type of blood cancer called 8p11 myeloproliferative syndrome. This condition is characterized by an increased number of white blood cells (myeloproliferative disorder) and the development of lymphoma, a blood-related cancer that causes tumor formation in the lymph nodes.
Where is Pdgfr located?
There are two PDGFR genes (PDGFRA and PDGFRB), and they reside on chromosome 4 and 5 in humans and 5 and 18 in mice, respectively. In both cases they are typical receptor tyrosine kinases (RTKs) that encode a transmembrane protein with an extracellular ligand binding domain and an intracellular tyrosine kinase domain.
What is the FGFR3 gene?
A gene that makes a protein that is involved in cell division, cell maturation, formation of new blood vessels, wound healing, and bone growth, development, and maintenance. A mutation (change) in the FGFR3 gene may cause the FGFR3 protein to become overactive in certain bone disorders, genetic conditions, and cancers.
What are FGFR mutations?
FGFR3 gene mutations change single amino acids in the FGFR3 protein, which appears to overactivate protein signaling. As a result, bladder cells are likely directed to grow and divide abnormally. This uncontrolled cell division leads to the formation of bladder cancer.
Is FGFR1 an oncogene?
FGFR1 and FGFR4 have been described as oncogenes in many types of cancer, including lung cancer. FGFR1 amplification was associated to FGFR inhibitor (FGFRi) sensitivity in preclinical studies.
What is the Met gene?
Listen to pronunciation. (… jeen) A gene that makes a protein that is involved in sending signals within cells and in cell growth and survival.
How is PDGFR activated?
Platelet-derived growth factor receptor (PDGFR) is activated by binding to its ligand PDGF, and involved in a variety of cellular processes, e.g. proliferation, migration, survival, and cancer development1.
What is CD140a?
CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells. Nat Biotechnol.
Where is FGFR3 located?
FGFR3, a tyrosine kinase receptor gene, is located at chromosome 4p16. 3 and is composed of 19 exons [14]. The extracellular portion can bind with fibroblast growth factors, initiating cascades of downstream signals that ultimately influence cell growth, migration, angiogenesis, and differentiation [14].
Where is the FGFR2 gene located?
Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10.
What are FGFR fusions?
Chromosomal rearrangements leading to FGFR gene fusions have been also found to be involved in the pathogenesis of human cancer. Gene fusions are hybrid genes that originate from the chromosomal rearrangement of two genes, in the form of translocation, insertion, inversion, and deletion [4].
How do FGFR inhibitors work?
Fibroblast growth factor receptor (FGFR) inhibitor; FGFRs are a family of receptor tyrosine kinases. Inhibition of FGFR phosphorylation and signaling decreases cell viability in cell lines expressing FGFR genetic alterations, including point mutations, amplifications, and fusions.
What does the FGFR1 gene do?
The FGFR1 gene provides instructions for making a protein called fibroblast growth factor receptor 1.
Where is the FGFR1 protein located on the cell membrane?
The FGFR1 protein spans the cell membrane, so that one end of the protein is inside the cell and the other end projects from the outer surface of the cell.
What is the pathophysiology of mir-195-5p/fgfr1 gene amplifications?
CCND1 and FGFR1 gene amplifications are associated with reduced benefit from aromatase inhibitors in metastatic breast cancer. Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer. Atractylenolide III predisposes miR-195-5p/FGFR1 signaling axis to exert tumor-suppressive functions in liver cancer.
What does FGFR stand for?
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution.