What are symptoms of monilethrix?
Monilethrix is a rare inherited disorder characterized by sparse, dry, and/or brittle hair that often breaks before reaching more than a few inches in length. The hair may lack luster, and there may be patchy areas of hair loss (alopecia).
How is monilethrix treated?
No definitive therapy is recognized, but topical minoxidil 2% (1 mL night and day for 1 y) led to an increase of normal hair shaft without any adverse effects in one report. Topical minoxidil 2% may be a good therapeutic option to treat monilethrix, although its use in children may require enhanced monitoring.
What causes Trichothiodystrophy?
What causes trichothiodystrophy? Trichothiodystrophy is caused by defective DNA repair and transcription and is inherited in an autosomal recessive pattern, meaning both parents must carry a copy of the mutated gene that causes trichothiodystrophy for a child to inherit the condition.
What does Trichorrhexis Nodosa mean?
Trichorrhexis nodosa is a common hair problem in which thickened or weak points (nodes) along the hair shaft cause your hair to break off easily.
What causes monilethrix?
Monilethrix is caused by mutations in one of several genes. Mutations in the KRT81 gene, the KRT83 gene, the KRT86 gene, or the DSG4 gene account for most cases of monilethrix. These genes provide instructions for making proteins that give structure and strength to strands of hair.
Is beaded hair a disease?
Monilethrix (also referred to as beaded hair) is a rare autosomal dominant hair disease that results in short, fragile, broken hair that appears beaded. It comes from the Latin word for necklace (monile) and the Greek word for hair (thrix).
What is monilethrix caused from?
What is Trichothiodystrophy disease?
Trichothiodystrophy, which is commonly called TTD, is a rare inherited condition that affects many parts of the body. The hallmark of this condition is brittle hair that is sparse and easily broken. Tests show that the hair is lacking sulfur, an element that normally gives hair its strength.
What causes TTD?
TTD is a genetically heterogenous condition. This means that mutations in several different genes may be responsible for the syndrome. Many patients with TTD have abnormalities in genes involved in the nucleotide excision repair pathway which is responsible for repairing DNA damage caused by ultraviolet radiation.
What is Trichostasis spinulosa?
Trichostasis spinulosa (TS) is a condition where instead of one hair protruding from a hair follicle, a bundle or bush of hair come out of a single follicle. This results in elevated, dark spiny papules on the head, face (usually the nose), and trunk.
What does monilethrix mean in medical terms?
Monilethrix is characterized by a beaded appearance of the hair due to periodic thinning of the shaft. This condition results in hair fragility and patchy dystrophic alopecia (hair loss) The term Monilethrix is derived from the Latin word monile, which means necklace, and the Greek word thrix, which means hair.
What are the symptoms of monilethrix?
Symptoms. Monilethrix is characterized by a beaded appearance of the hair due to periodic thinning of the shaft. This condition results in hair fragility and patchy dystrophic alopecia (hair loss). The term monilethrix is derived from the Latin word monile, which means necklace, and the Greek word thrix, which means hair.
How is monilethrix inherited?
In most cases, monilethrix is inherited as an autosomal dominant trait. In most cases of monilethrix, the hair is normal at birth; it may then be slowly replaced by abnormal hair during the first few months to two years of life. In some rare cases, the hair may be abnormal at birth (congenital).
What is the difference between dystrophic and monilethrix?
People with monilethrix also have sparse hair growth (hypotrichosis) and short, brittle hair that breaks easily. Expression of monilethrix is variable; in mild cases, dystrophic hair may be confined to the occiput but more severely affected individuals have near total hair loss.