What is the wobble theory?
A theory to explain the partial degeneracy of the genetic code due to the fact that some t-RNA molecules can recognize more than one codon. The theory proposes that the first two bases in the codon and anticodon will form complementary pairs in the normal antiparallel fashion.
Who gave the concept of Wobble Hypothesis?
To explain the possible cause of degeneracy of codons, in 1966, Francis Crick proposed “the Wobble hypothesis”. means to sway or move unsteadily). The phenomenon permits a single tRNA to recognize more than one codon.
What is the wobble position and what is its function?
The wobble position of a codon refers to the 3rd nucleotide in a codon. This nucleotide has two major characteristics: Binding of a codon in an mRNA the cognate tRNA is much “looser” in the third position of the codon. This permits several types of non-Watson–Crick base pairing to occur at the third codon position.
What does wobble pairing refer to?
A wobble base pair is a pairing between two nucleotides in RNA molecules that does not follow Watson-Crick base pair rules. Wobble base pairs are fundamental in RNA secondary structure and are critical for the proper translation of the genetic code.
What is wobble hypothesis Class 12?
Wobble hypothesis states the degeneracy of the genetic code. The pairing of the third base varies according to the base at the third position, for example, G may pair with U. The conventional pairing (A = U, G = C) is called Watson-Crick pairing and the second abnormal pairing is called wobble pairing.
Why is wobble beneficial to cell economy?
This flexibility at the “wobble” position allows some tRNAs to pair with two or three codons, thereby reducing the number of tRNAs required for translation. The following “wobble” rules mean that the 61 codons (for 20 amino acids) can be read by as few as 31 anticodons (or 31 tRNAs).
What is the importance of Wobble Hypothesis?
The Wobble Hypothesis explains why multiple codons can code for a single amino acid. This hence explains why more codons exist than there are specific tRNA molecules. The Wobble Hypothesis also illustrates why the only variability between many codons, that encode the same amino acid, is their 3rd base.
What is the importance of wobble hypothesis?
Who discovered DNA code?
Francis Crick and the Discovery of the Genetic Code | Learn Science at Scitable.
What is the wobble hypothesis?
Crick (1966) proposed the ‘wobble hypothesis’ to explain the degeneracy of the genetic code. Except for tryptophan and methionine, more than one codons direct the synthesis of one amino acid.
Does the wobble hypothesis explain redundancy in anticodons?
By direct sequence of several tRNA molecules, the wobble hypothesis is confirmed which explains the pattern of redundancy in genetic code in some anticodons (e.g. the anticodons containing U, I and G in the first position in 5’→ 3′ direction) The seryl-tRNA anticodon (UCG) 5′-GCU-3′ base pairs with two serine codons, 5′-AGC-3′ and 5′-AGU-3′.
What is the thermodynamic stability of wobble base pairs?
The thermodynamic stability of a wobble base pair is comparable to that of a Watson-Crick base pair. Wobble base pairs are fundamental in RNA secondary structure and are critical for the proper translation of the genetic code. Wobbling allows faster dissociation of tRNA from mRNA and also protein synthesis.
What is the theory of evolution?
The theory of evolution is a shortened form of the term “theory of evolution by natural selection,” which was proposed by Charles Darwin and Alfred Russel Wallace in the nineteenth century.